ISUP Publications

2026

Redefining the Landscape of Genitourinary Cancer Precursors: The International Society of Urological Pathology Consensus Recommendations

Cheng L, Iczkowski K, van Leenders G, Downes MR, Raspollini MR, Williamson SR, Moch H, Bremmer F, Tickoo SK, Menon S, Cubilla AL, Kristiansen; Members of the ISUP GU Cancer Precursor Consensus Panel. The Italy Consensus on Precursor Lesions of Genitourinary Organs. Redefining the Landscape of Genitourinary Cancer Precursors: The International Society of Urological Pathology Consensus Recommendations. European Urology, 2026. doi: 10.1016/j.eururo.2026.03.006. In Press.

Link: https://www.europeanurology.com/article/S0302-2838(26)02041-5/fulltext

International Society of Urological Pathology (ISUP) Multidisciplinary Consensus Conference on Premalignant and Precursor Lesions of the Genitourinary Organs: Current Evidence and Future Directions

Cheng L, Kristiansen G. International Society of Urological Pathology (ISUP) Multidisciplinary Consensus Conference on Premalignant and Precursor Lesions of the Genitourinary Organs: Current Evidence and Future Directions. Am J Surg Pathol. 2026 Mar 27. doi: 10.1097/PAS.0000000000002542. PMID: 41891794.

Link: https://pubmed.ncbi.nlm.nih.gov/41891794/

International Society of Urological Pathology (ISUP) Consensus Conference on Precursor Lesions: Working Group 4 Precursor Lesions of Testis Results of a Premeeting Survey

Bremmer F, Colecchia M, Collins K, Acosta AM, Gupta S, Gordetsky JB, Maclean F, Meyts ER, Dieckmann KP, Kaushal S, Srigley JR, Adra N, Gilligan T, Daugaard G, Looijenga LHJ, Kristiansen G, Cheng L, Tickoo SK; Members of the ISUP GU Cancer Precursor Consensus Panel. International Society of Urological Pathology (ISUP) Consensus Conference on Precursor Lesions: Working Group 4 Precursor Lesions of Testis Results of a Premeeting Survey. Am J Surg Pathol. 2026 Feb 23. doi: 10.1097/PAS.0000000000002523. PMID: 41724745.

Link: https://pubmed.ncbi.nlm.nih.gov/41724745/

The Genitourinary Pathology Society and International Society of Urological Pathology Joint Expert Consultation Recommendations on intraductal carcinoma of the prostate

Shah RB, Varma M, Zhou M, Paner GP, Amin MB, Berney DM, Cheng L, Deng FM, Downes M, Eggener S, Ehdaie B, Epstein JI, Evans A, Fine SW, Greenland N, Guo C, Han B, Hirsch MS, Izkowski KA, Kench JG, Lotan TL, Magi-Galluzzi C, Miyamoto H, Nguyen JK, Tsuzuki T, van der Kwast TH, van Leenders GJ, Williamson SR, Wobker SE, Wu CL, Yang X, Kristiansen G. The Genitourinary Pathology Society and International Society of Urological Pathology Joint Expert Consultation Recommendations on intraductal carcinoma of the prostate. Histopathology. 2026 Jan;88(1):8-23. doi: 10.1111/his.70046. PMID: 41384645; PMCID: PMC12700062.

Link: https://onlinelibrary.wiley.com/doi/10.1111/his.70046

The Dublin International Society of Urological Pathology (ISUP) Consensus Conference on Best Practice Recommendations on the Pathology of Glandular Lesions of the Urinary Bladder

Paner GP, Al-Ahmadie H, Gaisa NT, Lopez-Beltran A, Maclean F, Tsuzuki T, Werneck da Cunha I, Amin MB, Aning J, Aron M, Athanazio D, Bambury RM, Cheng L, Gopalan A, Gulmann C, Guo CC, Harris C, Iyer G, Jimenez RE, Jinzaki M, Kikuchi E, Lal P, Miyai K, Netto GJ, Pan CC, Panebianco V, van Rhijn BW, Siefker-Radtke A, Smith SC, Szarvas T, Wobker SE, Kristiansen G, Reis H; ISUP Expert Panel On Urachal Neoplasms and Urinary Bladder Glandular Lesions. The Dublin International Society of Urological Pathology (ISUP) Consensus Conference on Best Practice Recommendations on the Pathology of Glandular Lesions of the Urinary Bladder. Adv Anat Pathol. 2026 Jan 1;33(1):1-16. doi: 10.1097/PAP.0000000000000510. PMID: 40757456.

Link: https://pubmed.ncbi.nlm.nih.gov/40757456/

2025

Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer

Shah RB, Paner GP, Cheng L, De Marzo AM, Magi-Galluzzi C, Varma M, Zhou M, Amin A, Amin MB, Aron M, Cunha IW, Epstein JI, Fine SW, Haider A, Iczkowski KA, Kench JG, Kunju LP, Mohanty SK, Montironi R, Netto GJ, Pan CC, Rao P, Srigley JR, Sauter G, Tan PH, Tsuzuki T, van der Kwast TH, van Leenders GJ, Kristiansen G. Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer. Am J Surg Pathol. 2025 Dec 1;49(12):e27-e32. doi: 10.1097/PAS.0000000000002425. Epub 2025 May 30. PMID: 40444986; PMCID: PMC12509221.

Link: https://pubmed.ncbi.nlm.nih.gov/40444986/

International Society of Urological Pathology Consensus on Cancer Precursor Lesions. Working Group 1: The Prostate

Iczkowski KA, De Marzo AM, Agarwal N, Berman DM, Cimadamore A, Fine SW, Greenland N, Khani F, Loda M, Lotan TL, Varma M, Chinnaiyan A, Giannarini G, Huang J, Montironi R, Netto GJ, Osunkoya AO, Ratliff T, Kristiansen G, Cheng L, van Leenders GJLH; Members of the ISUP GU Cancer Precursor Consensus Panel. International Society of Urological Pathology Consensus on Cancer Precursor Lesions. Working Group 1: The Prostate. Am J Surg Pathol. 2025 Dec 1;49(12):e33-e45. doi: 10.1097/PAS.0000000000002430. PMID: 40545966; PMCID: PMC12754735.

Link: https://pubmed.ncbi.nlm.nih.gov/40545966/

International Society of Urological Pathology Consensus Meeting 2024: Working Group 2 Preneoplastic and Precursor Lesions of the Urinary Bladder

Downes MR, Lopez-Beltran A, Contieri R, Hansel DE, Paner GP, Shen S, van Rhijn BWG, Al-Ahmadie H, Amin MB, Brunelli M, Comperat E, Cookson MS, Faltas BM, Guo CC, Hartmann A, Kamat AM, Mertens LS, Ross JS, van der Kwast TH, Warrick J, Kristiansen G, Cheng L, Raspollini MR; Members of ISUP GU Cancer Precursor Consensus Panel. International Society of Urological Pathology Consensus Meeting 2024: Working Group 2 Preneoplastic and Precursor Lesions of the Urinary Bladder. Am J Surg Pathol. 2025 Dec 1;49(12):e46-e57. doi: 10.1097/PAS.0000000000002440. PMID: 40590266.

Link: https://pubmed.ncbi.nlm.nih.gov/40590266/

International Society of Urological Pathology (ISUP) Multidisciplinary Consensus on Premalignant and Putative Precursor Lesions of Penile Cancer: Working Group 5 report on Terminology, Grading, and Molecular Testing Practices

Menon S, Sanchez DF, Chaux A, Giannico GA, Oliveira P, Necchi A, Regauer S, Speiss PE, Tamboli P, Tsuzuki T, Elsa F V, Kristiansen G, Cheng L, Cubilla A; Members of the ISUP GU Cancer Precursor Panel. International Society of Urological Pathology (ISUP) Multidisciplinary Consensus on Premalignant and Putative Precursor Lesions of Penile Cancer: Working Group 5 report on Terminology, Grading, and Molecular Testing Practices. Am J Surg Pathol. 2025 Aug 20. doi: 10.1097/PAS.0000000000002453. PMID: 40826809.

Link: https://pubmed.ncbi.nlm.nih.gov/40826809/

The Dublin International Society of Urological Pathology (ISUP) Consensus Conference on Best Practice Recommendations on the Pathology of Urachal Neoplasms

Reis H, Al-Ahmadie H, Gaisa NT, Lopez-Beltran A, Maclean F, Tsuzuki T, Werneck da Cunha I, Amin MB, Aning J, Aron M, Athanazio D, Bambury RM, Cheng L, Gopalan A, Gulmann C, Guo CC, Harris C, Iyer G, Jimenez RE, Jinzaki M, Kikuchi E, Lal P, Miyai K, Netto GJ, Pan CC, Panebianco V, van Rhijn BW, Siefker-Radtke A, Smith SC, Szarvas T, Wobker SE, Kristiansen G, Paner GP; ISUP Expert Panel on Urachal Neoplasms and Urinary Bladder Glandular Lesions. The Dublin International Society of Urological Pathology (ISUP) Consensus Conference on Best Practice Recommendations on the Pathology of Urachal Neoplasms. Am J Surg Pathol. 2025 Nov 1;49(11):e18-e26. doi: 10.1097/PAS.0000000000002416. PMID: 40471793.

Link: https://pubmed.ncbi.nlm.nih.gov/40471793/

Assessment and classification of sex cord-stromal tumours of the testis: recommendations from the testicular sex cord-stromal tumour (TESST) group, an Expert Panel of the Genitourinary Pathology Society (GUPS) and International Society of Urological Pathology (ISUP)

Acosta AM, Colecchia M, Comperat E, Cornejo KM, Gill AJ, Gupta S, Cheville JC, Idrees MT, Kao CS, Maclean F, Matoso A, Raspollini MR, Michalova K, Reyes Múgica M, Tickoo SK, Tsuzuki T, Ulbright TM, Williamson SR, Siegmund S, Sholl LM, Gonzalez-Peramato P, Berney DM. Assessment and classification of sex cord-stromal tumours of the testis: recommendations from the testicular sex cord-stromal tumour (TESST) group, an Expert Panel of the Genitourinary Pathology Society (GUPS) and International Society of Urological Pathology (ISUP). Histopathology. 2025 Nov;87(5):660-676. doi: 10.1111/his.15482. PMID: 40528632; PMCID: PMC12522033.

Link: https://onlinelibrary.wiley.com/doi/10.1111/his.15482

Observer Variation in the Diagnosis of Testicular Sex Cord-Stromal Tumors by a Genitourinary Pathology Society and International Society of Urological Pathology Panel: Paving the Way for a New Classification

Berney DM, Colecchia M, Comperat E, Cornejo KM, Gill AJ, Gupta S, Cheville JC, Idrees MT, Kao CS, Maclean F, Matoso A, Michalova K, Raspollini MR, Múgica MR, Tickoo SK, Tsuzuki T, Ulbright TM, Williamson SR, Siegmund S, Sholl LM, Gonzalez-Peramato P, Acosta AM. Observer Variation in the Diagnosis of Testicular Sex Cord-Stromal Tumors by a Genitourinary Pathology Society and International Society of Urological Pathology Panel: Paving the Way for a New Classification. Mod Pathol. 2025 Sep;38(9):100804. doi: 10.1016/j.modpat.2025.100804. Epub 2025 Jun 3. PMID: 40473112.

Link: https://www.modernpathology.org/article/S0893-3952(25)00100-0/fulltext

Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer: Call for a Multidisciplinary Approach

Shah RB, Paner GP, Cheng L, De Marzo AM, Magi-Galluzzi C, Varma M, Zhou M, Amin A, Amin MB, Aron M, Cunha IW, Epstein JI, Fine SW, Haider A, Iczkowski KA, Kench JG, Kunju LP, Mohanty SK, Montironi R, Netto GJ, Pan CC, Rao P, Srigley JR, Sauter G, Tan PH, Tsuzuki T, van der Kwast TH, van Leenders GJ, Kristiansen G. Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer: Call for a Multidisciplinary Approach. Eur Urol. 2025 Jul;88(1):8-10. doi: 10.1016/j.eururo.2025.02.029. PMID: 40102113.

Link: https://www.sciencedirect.com/science/article/pii/S0302283825001502

2024

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer: Progresses and Challenges

van der Kwast TH, Bubendorf L, Cheng L. International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer: Progresses and Challenges. Am J Surg Pathol. 2024 Jan 1;48(1):1-3. doi: 10.1097/PAS.0000000000002066. Epub 2023 Jun 8. PMID: 37288838.

Link: https://pubmed.ncbi.nlm.nih.gov/37288838/

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 1: Comparison of Bladder Cancer Grading System Performance

Downes MR, Hartmann A, Shen S, Tsuzuki T, van Rhijn BWG, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel. International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 1: Comparison of Bladder Cancer Grading System Performance. Am J Surg Pathol. 2024 Jan 1;48(1):e1-e10. doi: 10.1097/PAS.0000000000002059. PMID: 37246824.

Link: https://pubmed.ncbi.nlm.nih.gov/37246824/

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas

Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel. International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas. Am J Surg Pathol. 2024 Jan 1;48(1):e11-e23. doi: 10.1097/PAS.0000000000002077. PMID: 37382156.

Link: https://pubmed.ncbi.nlm.nih.gov/37382156/

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer: Working Group 3: Subcategorization of T1 Bladder Cancer

Lopez-Beltran A, Raspollini MR, Hansel D, Compérat E, Williamson SR, Liedberg F, Iczkowski KA, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel. International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer: Working Group 3: Subcategorization of T1 Bladder Cancer. Am J Surg Pathol. 2024 Jan 1;48(1):e24-e31. doi: 10.1097/PAS.0000000000002121. PMID: 37737692.

Link: https://pubmed.ncbi.nlm.nih.gov/37737692/

International Society of Urological Pathology Consensus Conference on Current Issues in Bladder Cancer. Working Group 4: Molecular Subtypes of Bladder Cancer-Principles of Classification and Emerging Clinical Utility

Warrick JI, Al-Ahmadie H, Berman DM, Black PC, Flaig TW, Höglund M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel. International Society of Urological Pathology Consensus Conference on Current Issues in Bladder Cancer. Working Group 4: Molecular Subtypes of Bladder Cancer-Principles of Classification and Emerging Clinical Utility. Am J Surg Pathol. 2024 Jan 1;48(1):e32-e42. doi: 10.1097/PAS.0000000000002053. PMID: 37199442.

Link: https://pubmed.ncbi.nlm.nih.gov/37199442/

2023

International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members

Beijert IJ, Cheng L, Liedberg F, Plass K, Williamson SR, Gontero P, Ribal MJ, Babjuk M, Black PC, Kamat AM, Algaba F, Berman DM, Hartmann A, Masson-Lecomte A, Rouprêt M, Lopez-Beltran A, Samaratunga H, Shariat SF, Mostafid AH, Varma M, Shen S, Burger M, Tsuzuki T, Palou J, Compérat EM, Sylvester RJ, van der Kwast TH, van Rhijn BWG, Downes MR. International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members. Eur Urol Open Sci. 2023 May 10;52:154-165. doi: 10.1016/j.euros.2023.03.019. PMID: 37284047.

Link: https://pubmed.ncbi.nlm.nih.gov/37284047/

2020

Report From the International Society of Urological Pathology (ISUP) Consultation Conference On Molecular Pathology Of Urogenital Cancers. II. Molecular Pathology of Bladder Cancer: Progress and Challenges

Warrick JI, Knowles MA, Yves A, van der Kwast T, Grignon DJ, Kristiansen G, Egevad L, Hartmann A, Cheng L. Report From the International Society of Urological Pathology (ISUP) Consultation Conference On Molecular Pathology Of Urogenital Cancers. II. Molecular Pathology of Bladder Cancer: Progress and Challenges. Am J Surg Pathol. 2020 Jul;44(7):e30-e46. doi: 10.1097/PAS.0000000000001453. PMID: 32091435.

Link: https://pubmed.ncbi.nlm.nih.gov/32091435/

2019

Controversial issues in Gleason and International Society of Urological Pathology (ISUP) prostate cancer grading: proposed recommendations for international implementation

Srigley JR, Delahunt B, Samaratunga H, Billis A, Cheng L, Clouston D, Evans A, Furusato B, Kench J, Leite K, MacLennan G, Moch H, Pan CC, Rioux-Leclercq N, Ro J, Shanks J, Shen S, Tsuzuki T, Varma M, Wheeler T, Yaxley J, Egevad L. Controversial issues in Gleason and International Society of Urological Pathology (ISUP) prostate cancer grading: proposed recommendations for international implementation. Pathology. 2019 Aug;51(5):463-473. doi: 10.1016/j.pathol.2019.05.001. PMID: 31279442.

Link: https://pubmed.ncbi.nlm.nih.gov/31279442/

2013

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Srigley JR, Delahunt B, Eble JN, Egevad L, Epstein JI, Grignon D, Hes O, Moch H, Montironi R, Tickoo SK, Zhou M, Argani P; ISUP Renal Tumor Panel. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. Am J Surg Pathol. 2013 Oct;37(10):1469-89. doi: 10.1097/PAS.0b013e318299f2d1. PMID: 24025519.

Link: https://pubmed.ncbi.nlm.nih.gov/24025519/

Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations

Trpkov K, Grignon DJ, Bonsib SM, Amin MB, Billis A, Lopez-Beltran A, Samaratunga H, Tamboli P, Delahunt B, Egevad L, Montironi R, Srigley JR; members of the ISUP Renal Tumor Panel. Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations. Am J Surg Pathol. 2013 Oct;37(10):1505-17. doi: 10.1097/PAS.0b013e31829a85d0. PMID: 24025521.

Link: https://pubmed.ncbi.nlm.nih.gov/24025521/

The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters

Delahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, Egevad L, Algaba F, Moch H, Grignon DJ, Montironi R, Srigley JR; Members of the ISUP Renal Tumor Panel. The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters. Am J Surg Pathol. 2013 Oct;37(10):1490-504. doi: 10.1097/PAS.0b013e318299f0fb. PMID: 24025520.

Link: https://pubmed.ncbi.nlm.nih.gov/24025520/

2011

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 1: specimen handling

Samaratunga H, Montironi R, True L, Epstein JI, Griffiths DF, Humphrey PA, van der Kwast T, Wheeler TM, Srigley JR, Delahunt B, Egevad L; ISUP Prostate Cancer Group. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 1: specimen handling. Mod Pathol. 2011 Jan;24(1):6-15. doi: 10.1038/modpathol.2010.178. PMID: 20834234.

Link: https://pubmed.ncbi.nlm.nih.gov/20834234/

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume

van der Kwast TH, Amin MB, Billis A, Epstein JI, Griffiths D, Humphrey PA, Montironi R, Wheeler TM, Srigley JR, Egevad L, Delahunt B; ISUP Prostate Cancer Group. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume. Mod Pathol. 2011 Jan;24(1):16-25. doi: 10.1038/modpathol.2010.156. PMID: 20818340.

Link: https://pubmed.ncbi.nlm.nih.gov/20818340/

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 4: seminal vesicles and lymph nodes

Berney DM, Wheeler TM, Grignon DJ, Epstein JI, Griffiths DF, Humphrey PA, van der Kwast T, Montironi R, Delahunt B, Egevad L, Srigley JR; ISUP Prostate Cancer Group. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 4: seminal vesicles and lymph nodes. Mod Pathol. 2011 Jan;24(1):39-47. doi: 10.1038/modpathol.2010.160. PMID: 20818343.

Link: https://pubmed.ncbi.nlm.nih.gov/20818343/

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 5: surgical margins

Tan PH, Cheng L, Srigley JR, Griffiths D, Humphrey PA, van der Kwast TH, Montironi R, Wheeler TM, Delahunt B, Egevad L, Epstein JI; ISUP Prostate Cancer Group. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 5: surgical margins. Mod Pathol. 2011 Jan;24(1):48-57. doi: 10.1038/modpathol.2010.155. PMID: 20729812.

Link: https://pubmed.ncbi.nlm.nih.gov/20729812/