June 2026
Dear Esteemed ISUP Members and Colleagues:
We are pleased to share a series of landmark publications arising from the International Society of Urological Pathology (ISUP) Consensus Conference on Genitourinary Cancer Precursor Lesions. These multidisciplinary efforts bring together leading experts in pathology, urology, oncology, and translational research to establish contemporary recommendations and identify areas for future investigation across the spectrum of precursor and premalignant lesions of the genitourinary tract.
The following Working Group reports are now available:
Working Group 1: Precursor Lesions of the Prostate
Iczkowski KA, De Marzo AM, Agarwal N, Berman DM, Cimadamore A, Fine SW, Greenland N, Khani F, Loda M, Lotan TL, Varma M, Chinnaiyan A, Giannarini G, Huang J, Montironi R, Netto GJ, Osunkoya AO, Ratliff T, Kristiansen G, Cheng L, van Leenders GJLH; Members of the ISUP GU Cancer Precursor Consensus Panel. Am J Surg Pathol. 2025 Dec 1;49(12):e33-e45. PMID: 40545966.
Working Group 2: Preneoplastic and Precursor Lesions of the Urinary Bladder
Downes MR, Lopez-Beltran A, Contieri R, Hansel DE, Paner GP, Shen S, van Rhijn BWG, Al-Ahmadie H, Amin MB, Brunelli M, Comperat E, Cookson MS, Faltas BM, Guo CC, Hartmann A, Kamat AM, Mertens LS, Ross JS, van der Kwast TH, Warrick J, Kristiansen G, Cheng L, Raspollini MR; Members of ISUP GU Cancer Precursor Consensus Panel. Am J Surg Pathol. 2025 Dec 1;49(12):e46-e57. PMID: 40590266.
Working Group 3: Preneoplastic and Precursor Lesions of the Kidney
Williamson SR, Wobker SE, Mehra R, Al-Obaidy KI, Martignoni G, Mohanty S, Smith SC, Tan PH, Tretiakova M, Kapur P, Wu CL, Akgul M, Sangoi AR, Hakimi AA, Shuch B, Brugarolas J, Kristiansen G, Cheng L, Moch H; Members of the ISUP GU Cancer Precursor Consensus Panel. Am J Surg Pathol. 2026 Jun 1;50(6):e32-e47. PMID: 42054499.
Working Group 4: Precursor Lesions of the Testis
Bremmer F, Colecchia M, Collins K, Acosta AM, Gupta S, Gordetsky JB, Maclean F, Meyts ER, Dieckmann KP, Kaushal S, Srigley JR, Adra N, Gilligan T, Daugaard G, Looijenga LHJ, Kristiansen G, Cheng L, Tickoo SK; Members of the ISUP GU Cancer Precursor Consensus Panel. Am J Surg Pathol. 2026 Jun 1;50(6):e21-e31. PMID: 41724745
Working Group 5: Premalignant and Putative Precursor Lesions of the Penis
Menon S, Sanchez DF, Chaux A, Giannico GA, Oliveira P, Necchi A, Regauer S, Speiss PE, Tamboli P, Tsuzuki T, Elsa F V, Kristiansen G, Cheng L, Cubilla A; Members of the ISUP GU Cancer Precursor Panel. 2026 Jun 1;50(6):e6-e20. PMID: 40826809
These consensus publications provide evidence-based recommendations, address diagnostic challenges, and establish standardized terminology and reporting practices for precursor lesions throughout the genitourinary tract. Together, they represent a significant contribution toward improving diagnostic consistency, facilitating research, and enhancing patient care worldwide.
We congratulate all members of the ISUP GU Cancer Precursor Consensus Panel and thank the many contributors whose expertise made these important publications possible.
Warm regards,
Liang Cheng, MD, MSc
President, The International Society of Urological Pathology
Join or Renew Your ISUP Membership:
Become a Member/Pay Dues/Update Profile: https://isupweb.net/membership-join-pay-dues/
__________________________________________
May 2026
Dear Esteemed ISUP Members and Colleagues:
It is my great pleasure to share several exciting new initiatives, educational programs, and global engagement efforts from the International Society of Urological Pathology (ISUP). These endeavors reflect our continued commitment to advancing excellence in genitourinary pathology through innovation, collaboration, education, and worldwide outreach.
Multidisciplinary Expert Consultation Conference on Precision Biomarker Testing in GU Malignancies
We are delighted to announce that this important conference will take place on Saturday, September 12, 2026, from 7:30 AM to 1:30 PM in Stockholm, Sweden, immediately preceding the opening of the 38th European Congress of Pathology (ECP). The meeting will be held at the iconic Grand Hôtel Stockholm, located at Södra Blasieholmshamnen 8, 103 27 Stockholm, Sweden.
This highly anticipated conference will convene internationally renowned multidisciplinary experts to explore the rapidly evolving landscape of precision biomarker testing in bladder and prostate cancer. The working groups will address the clinical implementation of biomarker testing, standardized evidence-based approaches to interpretation and reporting, optimal specimen requirements and pre-analytical considerations, and the expanding role of liquid biopsy technologies.
The meeting will also highlight the transformative impact of artificial intelligence and digital pathology on biomarker assessment, workflow integration, and quality assurance. In addition, the working group panelists will identify key research priorities expected to shape future clinical trials, consensus recommendations, and guideline development.
Registration is now open at: https://isupweb.net/2025-isup-consensus-stockholm/ Or https://2026-isup-stockholm.eventbrite.com
Genito-Urinary Pathology Proficiency Test Program Officially Launched
ISUP is proud to introduce, for the first time, the Genito-Urinary (GU) Pathology Proficiency Test Program. This exciting educational initiative offers members an engaging opportunity to assess and strengthen their knowledge across the full spectrum of GU pathology.
The test consists of multiple-choice questions and is designed to serve as both a valuable learning experience and a demonstration of professional commitment to the field. Upon completion, participants will receive their scores along with detailed educational explanations, correct answers, and literature references that provide additional opportunities for learning and self-improvement.
We invite all members to participate by visiting the ISUP website at https://isupweb.net/, selecting “ISUP Resources,” and logging in to access the program
Global Engagement and Outreach Committee (GEOC) Officially Launched
We are thrilled to announce the establishment of the ISUP Global Engagement and Outreach Committee (GEOC), an important new initiative dedicated to strengthening ISUP’s international presence and fostering meaningful engagement across the global genitourinary pathology community, particularly in low- and middle-income countries.
Guided by the vision of “Connecting Genitourinary Pathologists Across the Globe,” the committee’s mission centers on education, best practice promotion, and global ambassadorship. Through regional seminars, international surveys, collaborative educational efforts, and initiatives aimed at advancing standardization in GU pathology, GEOC seeks to build stronger professional connections and expand access to high-quality educational resources worldwide. GEOC also launched the new ISUP Ambassadorship initiative. The committee will be conducting regional seminars, global surveys, promotion of standardizations, among others for LMICs.
ISUP GEOC is composed of Gladell P. Paner, MD (USA, Chair), Jeffrey S. So, MD (Philippines, co-chair for Eastern, Southern and Central Asia), Dilek Ertoy Baydar, MD (Turkey, co-chair for Eastern Europe, Western Asia and Africa), Isabel Alvarado-Cabrero, MD, PhD (Mexico, co-chair for Latin America and the Caribbean), Milagros Abad-Licham, MD, MsC (Peru), Turki Al Hussain, MD (Saudi Arabia), Daniel Athanazio, MD, PhD (Brazil), Busra Yaprak Bayrak, MD (Turkey), Huiying He, MD (China), Seema Kaushal, MD (India), Olufemi J. Ogunbiyi, MBBS (Nigeria), Qui Rao, MD, PhD (China), Jerasit Surintrspanont, MD (Thailand) and Anglita Yantisentiasti, MD (Indonesia).
Trainee, Education, and Mentorship Committee (TEAC) Officially Launched
We are equally pleased to introduce the new Trainee, Education, and Mentorship Committee (TEAC), established to strengthen engagement, education, and mentorship opportunities across the ISUP community.
Under the leadership of Professor Alessia Cimadamore and Professor Sean Williamson, the committee is committed to supporting trainees and early-career professionals while fostering an inclusive and collaborative environment for members at every stage of their careers. A major priority of the committee is to expand access to high-quality educational resources and create innovative opportunities for learning, professional development, and scholarly exchange.
The committee will also promote impactful mentorship relationships between experienced pathologists and trainees, encouraging career growth, collaboration, and individualized guidance.
In addition, TEAC will actively support a wide range of academic initiatives, including collaborative research projects, grand rounds, interesting case sharing, and slide seminars, all aimed at strengthening community engagement and advancing excellence in GU pathology education. We are excited about the positive impact this committee will have in empowering the next generation of pathologists while enriching the experience of all ISUP members.
Inaugural Grignon Education Award Lectureship
We are delighted to celebrate the tremendous success of the inaugural Grignon Education Award Lectureship, delivered by Professor Daniel M. Berney on May 5, 2026, through the ISUP Presents platform.
Professor Berney’s lecture, entitled “The Divine Comedy of Prostate Cancer: Hell, Purgatory, and Paradise,” was an inspiring and masterfully crafted presentation that beautifully integrated art, history, and histopathology. The lecture attracted more than 200 attendees from around the world and exemplified the creativity, scholarship, and educational excellence that define ISUP’s mission. The lecture recording is now available to members at https://isupweb.net/.
Inaugural Koss Medal Award Lectureship
We are honored to announce the upcoming inaugural ISUP Koss Medal Award Lectureship, featuring Professor Bogdan Czerniak. His lecture, entitled “The Mystery of Cancer Initiation: Lessons from Bladder Carcinogenesis,” will be presented on June 24, 2026, at 1:00 PM EST through the ISUP Presents platform.
This special event promises to provide fascinating insights into the mechanisms of bladder carcinogenesis and broader understanding of cancer initiation and progression. We warmly encourage all members to join us for what is certain to be an outstanding and thought-provoking lecture. Registration is available at:
https://us06web.zoom.us/webinar/register/WN_v5RrAzVJSZCGbTm59ME_gA
ISUP Publications Now Available Online
We are pleased to announce that all recent ISUP-sponsored publications (2011 – present) are now available on the ISUP website. This comprehensive collection provides members with centralized access to an important body of scholarly work, consensus recommendations, and educational resources that continue to shape the field of genitourinary pathology worldwide. The publications may be accessed at: https://isupweb.net/isup-publications/
Thank you once again for your continued support, dedication, and invaluable contributions to our specialty. Together, we are building a stronger, more connected, and more innovative global GU pathology community.
Wishing you a wonderful and relaxed summer!
Warm regards,
Liang Cheng, MD, MSc
President, The International Society of Urological Pathology
Join or Renew Your ISUP Membership:
Become a Member/Pay Dues/Update Profile: https://isupweb.net/membership-join-pay-dues/
__________________________________________
March 2026
It is my great pleasure to share several exciting new initiatives, educational programs, and global engagement efforts from the International Society of Urological Pathology (ISUP). These endeavors reflect our continued commitment to advancing excellence in genitourinary pathology through innovation, collaboration, education, and worldwide outreach.
Multidisciplinary Expert Consultation Conference on Precision Biomarker Testing in GU Malignancies
We are delighted to announce that this important conference will take place on Saturday, September 12, 2026, from 7:30 AM to 1:30 PM in Stockholm, Sweden, immediately preceding the opening of the 38th European Congress of Pathology (ECP). The meeting will be held at the iconic Grand Hôtel Stockholm, located at Södra Blasieholmshamnen 8, 103 27 Stockholm, Sweden.
This highly anticipated conference will convene internationally renowned multidisciplinary experts to explore the rapidly evolving landscape of precision biomarker testing in bladder and prostate cancer. The working groups will address the clinical implementation of biomarker testing, standardized evidence-based approaches to interpretation and reporting, optimal specimen requirements and pre-analytical considerations, and the expanding role of liquid biopsy technologies.
The meeting will also highlight the transformative impact of artificial intelligence and digital pathology on biomarker assessment, workflow integration, and quality assurance. In addition, the working group panelists will identify key research priorities expected to shape future clinical trials, consensus recommendations, and guideline development.
Registration is now open at: https://isupweb.net/2025-isup-consensus-stockholm/ Or https://2026-isup-stockholm.eventbrite.com
Genito-Urinary Pathology Proficiency Test Program Officially Launched
ISUP is proud to introduce, for the first time, the Genito-Urinary (GU) Pathology Proficiency Test Program. This exciting educational initiative offers members an engaging opportunity to assess and strengthen their knowledge across the full spectrum of GU pathology.
The test consists of multiple-choice questions and is designed to serve as both a valuable learning experience and a demonstration of professional commitment to the field. Upon completion, participants will receive their scores along with detailed educational explanations, correct answers, and literature references that provide additional opportunities for learning and self-improvement.
We invite all members to participate by visiting the ISUP website at https://isupweb.net/, selecting “ISUP Resources,” and logging in to access the program
Global Engagement and Outreach Committee (GEOC) Officially Launched
We are thrilled to announce the establishment of the ISUP Global Engagement and Outreach Committee (GEOC), an important new initiative dedicated to strengthening ISUP’s international presence and fostering meaningful engagement across the global genitourinary pathology community, particularly in low- and middle-income countries.
Guided by the vision of “Connecting Genitourinary Pathologists Across the Globe,” the committee’s mission centers on education, best practice promotion, and global ambassadorship. Through regional seminars, international surveys, collaborative educational efforts, and initiatives aimed at advancing standardization in GU pathology, GEOC seeks to build stronger professional connections and expand access to high-quality educational resources worldwide. GEOC also launched the new ISUP Ambassadorship initiative. The committee will be conducting regional seminars, global surveys, promotion of standardizations, among others for LMICs.
ISUP GEOC is composed of Gladell P. Paner, MD (USA, Chair), Jeffrey S. So, MD (Philippines, co-chair for Eastern, Southern and Central Asia), Dilek Ertoy Baydar, MD (Turkey, co-chair for Eastern Europe, Western Asia and Africa), Isabel Alvarado-Cabrero, MD, PhD (Mexico, co-chair for Latin America and the Caribbean), Milagros Abad-Licham, MD, MsC (Peru), Turki Al Hussain, MD (Saudi Arabia), Daniel Athanazio, MD, PhD (Brazil), Busra Yaprak Bayrak, MD (Turkey), Huiying He, MD (China), Seema Kaushal, MD (India), Olufemi J. Ogunbiyi, MBBS (Nigeria), Qui Rao, MD, PhD (China), Jerasit Surintrspanont, MD (Thailand) and Anglita Yantisentiasti, MD (Indonesia).
Trainee, Education, and Mentorship Committee (TEAC) Officially Launched
We are equally pleased to introduce the new Trainee, Education, and Mentorship Committee (TEAC), established to strengthen engagement, education, and mentorship opportunities across the ISUP community.
Under the leadership of Professor Alessia Cimadamore and Professor Sean Williamson, the committee is committed to supporting trainees and early-career professionals while fostering an inclusive and collaborative environment for members at every stage of their careers. A major priority of the committee is to expand access to high-quality educational resources and create innovative opportunities for learning, professional development, and scholarly exchange.
The committee will also promote impactful mentorship relationships between experienced pathologists and trainees, encouraging career growth, collaboration, and individualized guidance.
In addition, TEAC will actively support a wide range of academic initiatives, including collaborative research projects, grand rounds, interesting case sharing, and slide seminars, all aimed at strengthening community engagement and advancing excellence in GU pathology education. We are excited about the positive impact this committee will have in empowering the next generation of pathologists while enriching the experience of all ISUP members.
Inaugural Grignon Education Award Lectureship
We are delighted to celebrate the tremendous success of the inaugural Grignon Education Award Lectureship, delivered by Professor Daniel M. Berney on May 5, 2026, through the ISUP Presents platform.
Professor Berney’s lecture, entitled “The Divine Comedy of Prostate Cancer: Hell, Purgatory, and Paradise,” was an inspiring and masterfully crafted presentation that beautifully integrated art, history, and histopathology. The lecture attracted more than 200 attendees from around the world and exemplified the creativity, scholarship, and educational excellence that define ISUP’s mission. The lecture recording is now available to members at https://isupweb.net/.
Inaugural Koss Medal Award Lectureship
We are honored to announce the upcoming inaugural ISUP Koss Medal Award Lectureship, featuring Professor Bogdan Czerniak. His lecture, entitled “The Mystery of Cancer Initiation: Lessons from Bladder Carcinogenesis,” will be presented on June 24, 2026, at 1:00 PM EST through the ISUP Presents platform.
This special event promises to provide fascinating insights into the mechanisms of bladder carcinogenesis and broader understanding of cancer initiation and progression. We warmly encourage all members to join us for what is certain to be an outstanding and thought-provoking lecture. Registration is available at:
https://us06web.zoom.us/webinar/register/WN_v5RrAzVJSZCGbTm59ME_gA
ISUP Publications Now Available Online
We are pleased to announce that all recent ISUP-sponsored publications (2011 – present) are now available on the ISUP website. This comprehensive collection provides members with centralized access to an important body of scholarly work, consensus recommendations, and educational resources that continue to shape the field of genitourinary pathology worldwide. The publications may be accessed at: https://isupweb.net/isup-publications/
Thank you once again for your continued support, dedication, and invaluable contributions to our specialty. Together, we are building a stronger, more connected, and more innovative global GU pathology community.
Wishing you a wonderful and relaxed summer!
Warm regards,
Liang Cheng, MD, MSc
President, The International Society of Urological Pathology
Join or Renew Your ISUP Membership:
Become a Member/Pay Dues/Update Profile: https://isupweb.net/membership-join-pay-dues/
__________________________________________
February 2026
Dear Esteemed Members,
I’m writing to share some updates and reminders from the International Society of Urological Pathology (ISUP).
USCAP 2026 Annual Meeting
The ISUP Annual General Meeting (AGM) and Business Meeting will be held on Sunday, March 22, from 1:30–2:00 pm, in Stars at Night Ballroom B2, immediately preceding the ISUP Companion Society Meeting. The ISUP Stipend Awards and ISUP Excellence in Urologic Pathology Awards will be presented during the AGM and Business Meeting.
The ISUP Companion Society Meeting will take place on Sunday, March 22, from 2:00–4:00 pm, also in Stars at Night Ballroom B2, during the Annual USCAP Meeting in San Antonio, Texas, USA.
The theme for this year’s meeting is “Foundations and the Future in Urologic Pathology”.
Moderators: Dr Sean Williamson (Cleveland Clinic) and Dr Sara Wobker (UNC, Chapel Hill).
The speakers for this Companion Society Meeting are:
Dr Reza Alaghehbandan (Cleveland Clinic, USA) – “Papillary RCC: Past, Present and Future”
Dr Kvetoslava Michalova (Biopticka Labs, Czech Republic) – “Sertoli Cell Tumors and Related CTNNB1- Mutated Testicular Sex Cord Stromal Neoplasms”
Dr Alessia Cimadamore (Universitaria Integrata di Udine, Italy) – “Prostate Cancer: Evolution from Histometry to Digital Pathology and Artificial Intelligence”
Dr Steven Smith (University of Virginia, USA) – “From a Hyperplastic Foundation to a Molecular Future: Evolving Concepts in Adrenal Cortical Lesions”
Awards and Honors
The following Awards will be presented during the Companion Society Meeting:
David J Grignon Education Award
Koss Medal for Advancement of Urological Pathology
Grawitz Medal
For more information on each award please see the website: https://isupweb.net/awards-and-honors/
Call for Case of the Month (COTM) Submissions
If you have an interesting case to share, please email it to: cotm@isupweb.net. Please ensure all submissions are de-identified. Our COTM editor will confirm receipt and provide posting details.
Join or Renew Your ISUP Membership
To join or renew your membership, please visit https://isupweb.net/membership-join-pay-dues/
If you experience any issues with logging in or payment, please contact our webmaster at: support@isupweb.net
I look forward to seeing many of you next month in San Antonio.
Warm regards,
Liang Cheng, MD, MSc
President, The International Society of Urological Pathology
Join or Renew Your ISUP Membership:
Become a Member/Pay Dues/Update Profile: https://isupweb.net/membership-join-pay-dues/
__________________________________________
December 2025
Dear Esteemed Members,
As we enter the festive season, I’m writing to share some updates and reminders from the International Society of Urological Pathology (ISUP).
Join or Renew Your ISUP Membership
ISUP has implemented a standardized annual billing cycle for membership renewals, effective at the end of 2025. Under this new system, all memberships will renew at the end of each calendar year, and membership will be offered as a one-year term only, with the annual fee set at $100. The three-year membership option is no longer available.
For members currently on a one-year membership, your renewal will be due at the end of December 2025. Members who previously purchased a three-year membership will renew at the end of December 2026. To join or renew your membership, please visit https://isupweb.net/membership-join-pay-dues/
If you experience any issues with logging in or payment, please contact our webmaster at: support@isupweb.net
Awards and Honors:
On behalf of the international selection committee of the ISUP Stipend Award, Professor Trevor Flood, Professor Arndt Hartmann, Professor Chisato Ohe, Professor Steven Smith, and Professor Puay Hoon Tan, ISUP would like to solicit applications for the 2026 ISUP Stipend Award.
This award, which recognizes trainees in Pathology who have demonstrated interest, commitment, and early accomplishments in the study of Urological Pathology, provides a small stipend to support travel to a national/international meeting or an interinstitutional Urological Pathology study experience.
Interested applicants should send their curriculum vitae and a cover letter describing their commitment to, any relevant accomplishments in, and career plans for study of Urological Pathology to the selection committee chair, at isupstipendaward@gmail.com.
Applications received by January 10, 2026 will be reviewed by the committee with awardee(s) announced at the 2026 USCAP Meeting.
For more details on all ISUP awards, including committee members and application dates, please see: https://isupweb.net/awards-and-honors/.
USCAP 2026 Annual Meeting:
The ISUP AGM and Business Meeting will be held between 1.30-2pm in “Stars at Night Ballroom B2” on March 22 immediately preceding the Companion Society Meeting.
The ISUP Companion Society Meeting at the Annual USCAP meeting (San Antonio, Texas, USA) will be held on Sunday, March 22 in the “Stars at Night Ballroom B2” between 2-4pm. The moderators are Dr Sean Williamson (Cleveland Clinic) and Dr Sara Wobker (UNC, Chapel Hill).
The speakers for this event are:
Dr Reza Alaghehbandan (Cleveland Clinic, USA) – Papillary RCC: Past, Present and Future
Dr Kvetoslava Michalova (Biopticka Labs, Czech Republic) – Sertoli Cell Tumors and Related CTNNB1- Mutated Testicular Sex Cord Stromal Neoplasms
Dr Alessia Cimadamore (Universitaria Integrata di Udine, Italy) – Prostate Cancer: Evolution from Histometry to Digital Pathology and Artificial Intelligence
Dr Steven Smith (University of Virginia, USA) – From a Hyperplastic Foundation to a Molecular Future: Evolving Concepts in Adrenal Cortical Lesions
I wish all our members a joyous holiday season and a Happy New Year.
Warm regards,
Liang Cheng, MD, MS
President, The International Society of Urological Pathology
Join or Renew Your ISUP Membership:
Become a Member/Pay Dues/Update Profile: https://isupweb.net/membership-join-pay-dues/
__________________________________________
November 2025
Dear Esteemed Members,
I’m writing to share some updates and reminders from the International Society of Urological Pathology (ISUP).
New International Councillor- Australia
We are delighted to announce that Dr Fiona Maclean is the new International Councillor for Australia!
Dr Maclean is a senior histopathologist at Douglass Hanly Moir, Sydney and also a clinical advisor to Franklin AI. She holds multiple administrative positions at the national and international level and is a sought after speaker internationally. Her practice covers genitourinary and bone/soft tissue pathology. We thank Dr. Joanna Leith Perry-Keane for her work during her term as councillor and welcome Dr Fiona Maclean to the ISUP council.
Publications
Please see the December issue of the American Journal of Surgical Pathology (AJSP) for recent ISUP publications: International Society of Urological Pathology Consensus on Cancer Precursor Lesions. Working Group 1: The Prostate (PMID: 40545966), International Society of Urological Pathology Consensus Meeting 2024: Working Group 2 Preneoplastic and Precursor Lesions of the Urinary Bladder (PMID: 40590266) and a joint ISUP/GUPS paper: Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer (PMID: 40444986).
ICCR Dataset Updates
We are pleased to advise the final phase of open consultation for the updated ICCR Genitourinary datasets has now commenced.
The ICCR invite the International Society of Urological Pathology (ISUP) to review the following draft Urinary tract datasets:
Carcinoma of the bladder – cystectomy, cystoprostatectomy and diverticulectomy specimen (2nd edition)
Carcinoma of the renal pelvis and ureter – nephroureterectomy and ureterectomy specimen (2nd edition)
Carcinoma of the urethra – urethrectomy specimen (2nd edition)
Urinary tract carcinoma – biopsy and transurethral resection specimen (2nd edition)
The draft datasets are available for comment until Wednesday 3 December 2025 at: https://www.iccr-cancer.org/datasets/datasets-under-consultation/. To provide your feedback, please email any comments to datasets@iccr-cancer.org.
If you have any questions, please contact the ICCR Dataset Project Manager, Fleur Webster at fleurwebster@iccr-cancer.org.
Thank you once again for your support of these updates. The ISUP logo has been incorporated into the draft Urinary tract datasets.
Reminders
Awards and Honors:
The ISUP has numerous Awards and Honors that are presented on an annual basic including the David J. Grignon Education Award, the Koss Medal, the Grawitz Medal, the ISUP Stipend Awards and the ISUP Excellence in Urologic Pathology Award.
For more details on each award, including committee members and application dates, please see: https://isupweb.net/awards-and-honors/. We look forward to receiving many nominations for these prestigious awards.
Membership Renewal Reminder:
We are moving to an annual billing cycle for ISUP membership renewal starting end of 2025. This means all membership renewals will occur at the same time (end of year). Moving forward the membership will be for one year only (we are no longer offering a 3-year term) at $100 for the year. This rate is comparable to other international societies.
For those who are currently on a 1-year membership, your renewal will be end of December 2025. For those who have paid for a 3 year term, your renewal will commence end of December 2026. To renew your membership, please go to: https://isupweb.net/membership-join-pay-dues/
If you experience any issues with logging in or payment, please contact our webmaster at: support@isupweb.net
Warm regards,
Liang Cheng, MD, MS
President, The International Society of Urological Pathology
Join or Renew Your ISUP Membership:
Become a Member/Pay Dues/Update Profile: https://isupweb.net/membership-join-pay-dues/
__________________________________________
October 2025
Dear Esteemed Members,
I’m writing to share exciting updates from the International Society of Urological Pathology (ISUP) and a number of important initiatives.
Call for International Councillor- Australia:
Dr Joanna Leith Perry-Keene has completed her term as International Councillor for Australia which means that that we now need a new International Councillor for Australia!. If you are working in Australia and would like to be the representative in the ISUP council, we would like to hear from you! The deadline is mid-November (November 14th). Please send your CV and your mission statement with your application and forward to: info@isupweb.net
ISUP Website Update:
Due to unforeseen circumstances that were beyond the control of the ISUP council, the old website was removed from the internet. We have rebuilt the ISUP website which is now available at: www.isupweb.net.
Please note the website address is very similar to the old website (.net in place of .org). To ensure you are receiving all ISUP communications, please add the website address to your contacts. As this is a new website, we are still adding functionality but COTM, journal club and ISUP Presents are all available!
If you experience any challenges with login or access, our new webmaster is available to help. Please send your query to: support@isupweb.net and she will reply to you directly.
Membership Renewal Update:
We are moving to an annual billing cycle for ISUP membership renewal starting end of 2025. This means all membership renewals will occur at the same time (end of year). Moving forward the membership will be for one year only (we are no longer offering a 3-year term) at $100 for the year. This rate is comparable to other international societies.
For those who are currently on a 1-year membership, your renewal will be end of December 2025. For those who have paid for a 3 year term, your renewal will commence end of December 2026. To renew your membership, please go to: https://isupweb.net/membership-join-pay-dues/
If you experience any issues with logging in or payment, please contact our webmaster at: support@isupweb.net
Awards and Honors:
The ISUP has numerous Awards and Honors that are presented on an annual basic including the David J. Grignon Education Award, the Koss Medal, the Grawitz Medal, the ISUP Stipend Awards and the ISUP Excellence in Urologic Pathology Award.
For more details on each award, including committee members and application dates, please see: https://isupweb.net/awards-and-honors/. We look forward to receiving many nominations for these prestigious awards.
ISUP–GUPS Joint Initiatives: Strengthening Collaboration Through Consensus and Shared Scholarship:
The collaboration between the International Society of Urological Pathology (ISUP) and the Genitourinary Pathology Society (GUPS) has gained exceptional momentum in 2025, marked by the publication of the first joint white paper and the successful completion of a large-scale consultation on intraductal carcinoma of the prostate (IDCP).
The joint ISUP–GUPS White Paper on Defining Indolent Prostate Cancer: Call for a Multidisciplinary Approach (Eur Urol 2025; 88: 8–10) represents a major step forward in addressing the pervasive problem of overdiagnosis in prostate cancer. Rather than focusing narrowly on the semantics of renaming ISUP Grade Group 1 disease, the paper proposes a pragmatic, evidence-based framework to distinguish indolent from potentially progressive cancers. It defines indolent prostate cancer as a low-volume, well-differentiated acinar neoplasm confined to the gland that would not shorten life expectancy if left untreated. The document stresses that its optimal recognition cannot rely on histology alone but requires coordinated input from radiology (particularly mpMRI), clinical parameters, and molecular profiling. By delineating the conceptual difference between clinically insignificant and indolent prostate cancer, it calls for a new, multidisciplinary model in which pathologists, radiologists, and urologists share diagnostic responsibility to minimize overtreatment while safeguarding oncologic safety.
In parallel, a large joint GUPS–ISUP expert consultation on intraductal carcinoma of the prostate (IDCP) reached completion this summer. Co-chaired by Rajal B. Shah and Glen Kristiansen, the project involved 32 expert panelists and more than 200 participants at the Boston consensus conference during USCAP 2025. Using a modified Delphi process, the group reconciled prior differences between GUPS and ISUP regarding IDCP terminology, grading, and management. Consensus was achieved on nearly all major issues: IDCP should be diagnosed according to the Guo and Epstein criteria (with basal cell IHC in difficult cases), the term “AIP, suspicious for IDCP” should replace ambiguous borderline diagnoses, and the IDCP component should be incorporated into Gleason grading whenever associated with invasive carcinoma, irrespective of Grade Group. Importantly, active surveillance is deemed inappropriate for cases of GG 1 carcinoma with IDCP, and such cases should be reviewed in a multidisciplinary setting that includes mpMRI assessment. The final manuscript—The GUPS–ISUP Joint Expert Consultation Recommendations on Intraductal Carcinoma of the Prostate—is now in submission and expected to appear later this year/beginning of 2026.
These two major undertakings exemplify the growing integration between ISUP and GUPS: evidence-based consensus building, open international participation, and an emphasis on bridging pathology with clinical management. A third collaborative initiative, a joint ISUP–GUPS project on testicular sex-cord stromal tumors, led by Andres Acosta and Dan Berney, has already been launched and follows the same structured methodology.
Together, these activities underline a shared commitment to harmonize diagnostic standards, reduce interpretive variability, and foster a global, multidisciplinary dialogue that benefits both pathology and patient care.”
Vienna ISUP Multidisciplinary Expert Consultation Consensus Conference:
On September 11th 2025, the ISUP held a Multidisciplinary Expert Consultation Conference on the Evaluation of Treatment Effects in Prostate and Bladder Cancer at the Josephinum venue in Vienna. The half day meeting was well attended with excellent presentations and informative discussion. The resulting manuscripts are anticipated mid-2026. We thank our sponsors (Zeta Corporation and Daiichi-Sankyo) and acknowledge the help of our colleagues at the Department of Urology and Comprehensive Cancer Center at the Medical University of Vienna for all their assistance in hosting this event.
Warm regards,
Liang Cheng, MD, MS
President, The International Society of Urological Pathology
Join or Renew Your ISUP Membership:
August 2025
Dear Esteemed Members,
The International Society of Urological Pathology will host a Multidisciplinary Expert Consultation Conference on Treatment Effects of Prostate and Bladder Cancer on September 11, 2025, immediately following the 37th European Congress of Pathology.
Registration is still open: https://isup-vienna-2025.eventbrite.com or https://isupweb.net/events/
Please find below the final agenda for the meeting.
International Society of Urological Pathology (ISUP) Multidisciplinary Expert Consultation Conference
Treatment Effects in Prostate and Bladder Cancer
Conference Chairpersons: Liang Cheng & Geert JLH van Leenders
Time, Date & Location: 8:00 am – 1 pm on September 11, 2025, Vienna, Austria
Meeting Venue: Josephinum – Medizinische Sammlungen GmbH
Medizinische Universität Wien
Währinger Straße 25, 1090 Wien
Website: https://www.josephinum.ac.at
Registration: https://isup-vienna 2025.eventbrite.com or https://isupweb.net/events/
Agenda
8:00 – 8:30 am Arrival at Währinger Straße 25, 1090 Wien, Coffee and Registration
8:30 – 8:35 am Welcome & Opening Remarks
Liang Cheng & Geert van Leenders (Conference Chairpersons)
8:35 am – 12 noon Working Group Presentations and Voting
8:35 am – 10:00 am Working Group 1: Treatment Effects in Prostate Cancer
Introduction: Alessia Cimadamore & Gladell Paner (Co-chairs)
Subgroup 1: Radiation Therapy
Presenter: Fiona Mclean
Discussion, proposal and voting
Subgroup 2: Hormonal Therapy, Systemic Therapy, and Combinations
Presenter: Anuradha Gopalan
Discussion, proposal and voting
Subgroup 3: Ablation Therapy
Presenter: James Kench & Kenneth Iczkowski
Discussion, proposal and voting
10:00 am – 10:30 am Group Photo & Coffee Break
10:30 am – 11:55 noon Working Group 2: Treatment Effects in Bladder Cancer
Introduction: Michelle Downes & Antonio Lopez Beltran (Co-chairs)
Subgroup 1: Bladder cancer post systemic therapy (Presenter: Sara Wobker)
Subgroup 2: Bladder cancer and intravesical therapy (Presenter: Steven Smith)
Subgroup 3: Bladder cancer biology and disease monitoring
Presenter: Markus Eckstein & Antonio Lopez-Beltran
11:55- 12:00 Closing Remarks
Liang Cheng & Geert van Leenders (Conference Chairpersons)
12 – 1 pm Luncheon Seminar: HER2 Testing in Bladder Cancer
Presenter: Gladell Paner
Also please join us at the Grawitz Dinner Vienna on September 10 (Wed) from 5:30 PM, for an evening of fun and meet and greet before the ISUP conference. See details, venue, price and reservation in the link below.
https://www.eventbrite.com/e/1527667858689?aff=oddtdtcreator
We look forward to welcoming you to beautiful Vienna!
Warm regards,
The ISUP Council
__________________________________________
July 2025
Dear Esteemed Members,
I hope you are enjoying a relaxed and refreshing summer!
I am delighted to share several important updates and upcoming events from the International Society of Urological Pathology (ISUP).
We’re excited to announce the launch of our brand-new ISUP website: https://isupweb.net/ The site is now open to the public, and while it’s still a work in progress, more features and resources will be added soon. Please take a look and stay tuned for continued enhancements.
Mark your calendars! ISUP will host a Multidisciplinary Expert Consultation Conference on Treatment Effects of Prostate and Bladder Cancer on September 11, 2025, at the historic Josephinum in Vienna, immediately following the 37th European Congress of Pathology. Registration is now open: https://isup-vienna-2025.eventbrite.com We look forward to welcoming you to this exciting and high-impact event!
Over the past few months, our distinguished working group members have worked diligently to develop programs for the Vienna ISUP Multidisciplinary Expert Consultation Conference. Whether or not you plan to attend the Vienna meeting, we would greatly appreciate your insights. Please take a moment to complete our brief pre-meeting survey: https://www.surveymonkey.com/r/ZWQHT7K
The survey will close on August 4, 2025.
We are honored to host Dr. Mahmut Agkul from the Brigham and Women’s Hospital | Harvard Medical School, who will present “High-Grade Primary Kidney Tumors: The Ugly Five” on July 31, 2025 at 1:00 PM EST. We look forward to your participation in this engaging and insightful presentation. Please register for this zoom webinar using the following link: https://us06web.zoom.us/webinar/register/WN_Oq1box-BSHOBLqbD6s9KQQ#/registration
We invite you to contribute to our popular Case of the Month series on the ISUP website. If you have an educational case to share, please email it to: cotm@isupweb.net Please ensure all submissions are de-identified. Our COTM editor will confirm receipt and provide posting details.
We invite you to recommend or volunteer as a speaker for upcoming ISUP Presents sessions. Please send your suggestions (including speaker name and topic) to lectures@isupweb.net.
We welcome voices from across the globe!
Wishing you all a joyful and rejuvenating summer. Thank you for being part of our vibrant urologic pathology community!
Warm Regards,
Liang Cheng, MD, MS
President, The International Society of Urological Pathology