The 2024 ISUP Multidisciplinary Consensus Conference on Cancer Precursor Lesions of the Genitourinary Organs
On September 12, 2024, the International Society of Urological Pathology will host a “Multidisciplinary Consensus Conference on Cancer Precursor Lesions of the Genitourinary Organs“, open to members and non-member clinicians and scientists in pathology, urology, oncology, and related fields, immediately after the 36th European Congress of Pathology (ECP), in the beautiful city of Florence, Italy. This consensus will be in person, without a hybrid format.
This conference will be hosted at the Hotel Albani Firenze (address: Via Fiume, 12, 50123 Firenze FI, Italy). The hotel is approximately 450 meters away from the Congress Center, Fortezza da Basso.
The meeting objectives are:
– Define established and putative precursor lesions of genitourinary organs
– Refine classification scheme/terminology and diagnostic criteria
– Provide recommendations for pathology reporting
– Provide recommendations for ancillary studies and diagnostic work-up, including immunostaining and molecular testing in different clinical settings
– Provide literature review to aid developing guidelines for clinical management
This Consensus will be Co-Chaired by ISUP members, Dr. Liang Cheng (Providence, RI, USA), and Dr. Glen Kristiansen (Bonn, Germany)
The Consensus meeting will include 5 topics, including:
A. Precursor Lesions of the Prostate (Dr. Kenneth A. Iczkowski and Dr. Geert JLH van Leenders, co-Leads)
B. Precursor Lesions of the Urinary Bladder (Dr. Michelle R. Downes and Dr. Maria R. Raspollini, co-Leads)
C. Precursor Lesions of the Kidney (Dr. Sean R. Williamson and Dr. Holger Moch, co-Leads)
D. Precursor Lesions of the Testis (Dr. Felix Bremmer and Dr. Satish Tickoo, co-Leads)
E. Precursor Lesions of the Penis (Dr. Santosh Menon and Dr. Antonio L. Cubilla, co-Leads)
Each of these topics will be researched by one of five Working Groups, whose reviews will be informed in part based on a pre-meeting survey of the ISUP membership. Working Group findings will be presented to the membership for consensus voting at the meeting.
Agenda
8:00 – 8:20 am Arrival at via Fiume, 12, 50123 Firenze FI, Coffee and Registration
8:20 – 8:30 am Welcome & Opening Remarks (Conference Chairpersons: Liang Cheng and Glen Kristiansen)
8:30- 10:30 am Precursor Lesions of the Prostate (Working Group 1 Chairpersons: Kenneth Iczkowski & Geert van Leenders)
Subgroup 1 High grade prostatic intraepithelial neoplasia (HGPIN)
– Molecular origns of prostate cancer (Angelo DeMarzo)
– Historical perspectives and survey findings (Kenneth Iczkowski)
– Contemporary perspective (Murali Varma)
– Summary/Proposals/Voting/Final Statements (David Berman)
Subgroup 2 Intraductal carcinoma (IDC)
– Current perspective, molecular data, and differential diagnosis (Massimo Loda)
– Summary/Proposals/Voting/Final Statements (Massimo Loda)
Subgroup 3 Atypical intraductal proliferation (AIP)
– Diagnostic criteria (Nancy Greenland)
– Molecular correlates (Tamara Lotan)
– Clinicopathologic correlates (Alessia Cimadamore)
– Summary/Proposals/Voting/Final Statemens (Samson Fine)
Subgroup 4 Proliferative inflammatory atrophy and atypical adenomatous hyperplasia
– Current perspective & molecular evidence (Angelo DeMarzo)
– Summary/Proposals//Voting/Final Statements (Angelo DeMarzo)
10:30 – 10:45 am Coffee break
10:45 – 12:15 pm Precursor Lesions of the Urinary Bladder (Working Group 2 Chairpersons: Michelle Downes and Maria Raspollini )
Flat lesions Gladell Paner
Glandular lesions Antonio Lopez-Beltran
Papillary lesions Steven Shen
Squamous lesions Donna Hansel
Clinical focus Roberto Contieri
12:15 – 1:15 pm Group photo and lunch break
1:15 – 2:30 pm Precursor Lesions of the Kidney (Working Group 3 Chairpersons: Sean Williamson and Holger Moch )
Overview on selected topics and general concepts
- Progression pathways of ccRCC Holger Moch
- CCP tumor and PRCC progression Sean Williamson
- chRCC progression and cell of origin concept Rohit Mehra
Objective report of polled questions/Discussion/Voting Sean Williamson
Final statements and closing remarks Holger Moch
2:30 – 2:45 pm Coffee break
2:45 – 3:45 pm Precursor Lesions of the Testis (Working Group 4 Chairpersons: Felix Bremmer and Satish Tickoo)
Overview of testicular precursor lesions Felix Bremmer
Questionnaire data presentation Maurizio Colecchia
Summary/Proposals/Voting/Final Statements Katrina Collins and Satish Tickoo
3:45 – 4:55 pm Precursor Lesions of the Penis (Working Group 5 Chairpersons: Santosh Menon and Antonio Cubilla)
Overview of penile precursor lesions Antonio Cubilla
Objective report of polled questions Elsa Velazquez
Summary/Proposals/Discussion Pheroze Tamboli
Voting/Final statements Santosh Menon
4:55 – 5:00 pm Closing Remarks (Conference Chairpersons: Liang Cheng and Glen Kristiansen)
Support provided without relationship with scientific activities: Franklin.ai
Outcomes and Publications from the Consensus Panel
Cheng L, Iczkowski K, van Leenders G, Downes MR, Raspollini MR, Williamson SR, Moch H, Bremmer F, Tickoo SK, Menon S, Cubilla AL, Kristiansen; Members of the ISUP GU Cancer Precursor Consensus Panel. The Italy Consensus on Precursor Lesions of Genitourinary Organs. Redefining the Landscape of Genitourinary Cancer Precursors: The International Society of Urological Pathology Consensus Recommendations. European Urology, 2026. doi: 10.1016/j.eururo.2026.03.006. In Press.
Members of the ISUP GU Cancer Precursor Consensus Panel: Andres Acosta, Adebowale Adeniran, Nabil Adra, Neeraj Agarwal, Mahmut Akgul, Hikmat Al-Ahmadie, Ferran Algaba, Yves Allory, Khaleel Al-Obaidy, Mahul Amin, Georgios Andreou, Marc Barry, Dilek Baydar, David Berman, Stephania Bezerra, Felix Bremmer, James Brugarolas, Matteo Brunelli, Lukas Bubendorf, Katie Buzacott, Birgitte Carlsen, Alcides Chaux, Fei Chen, Liang Cheng, Arul Chinnaiyan, Roselyne Choiniere, Alessia Cimadamore, Maurizio Colecchia, Katrina Collins, Eva Comperat, Roberto Contieri, Michael Cookson, Antonio Cubilla, Francesca D’Souza, Alis Dema, Angelo DeMarzo, Gedske Daugaard, Regina de Paula Xavier Gomes, Klaus-Peter Dieckmann, Dejan Dobi, Michelle Downes, Andrew Erickson, Bishoy Faltas, Alexander Fichhtner, Samson Fine, Achim Fleischmann, Jacqueline Fontugne, Rongbin Ge, Gianluca Giannarini, Giovanna Giannico, Timothy Gilligan, Jennifer Gordetsky, Nancy Greenland, Raluca Grigorescu, Rainer Grobholz, Charles Guo, Sounak Gupta, Lavinia Hallam, Ari Hakimi, Donna Hansel, Arndt Hartmann, Loren Herrera Hernandez, Jiaoti Huang, Kenneth Iczkowski, Rafael Jimenez, Merce Jorda, Ashish Kamat, Payal Kapur, Seema Kaushal, James Kench, Margaret Knowles, Glen Kristiansen, Li Lei, Subodh Lele, João Lobo, Massimo Loda, Leendert Looijenga, Antonio Lopez-Beltran, Tamara Lotan, Anand Loya, Fiona Maclean, Alopa Malaviya, Guido Martignoni, Rohit Mehra, Santosh Menon, Laura Mertens, Holger Moch, Sambit Mohanty, Rodolfo Montironi, Helmut Mühleisen, Andrea Necchi, George Netto, Ngoc-Nhu Jennifer Nguyen, Maya Nourieh, Mikko Nyman, Pedro Oliveira, Declan O’Rourke, Adeboye Osunkoya, Gladell Paner, Ewa Rajpert-De Meyts, Maria Rosaria Raspollini, Timothy Ratliff, Sigrid Regauer, Henning Reis, Ohashi Riuko, Antonio Rodriguez-Calero, Jeffrey Ross, Diego Sanchez, Ankur Sangoi, Fanni Sánta, Steven Shen, Brian Shuch, Steven Smith, Philippe Spiess, John Srigley, Yue Sun, Sueli Suzigan, Nicole Swarbrick, Pheroze Tamboli, Puay Hoon Tan, Zahrah Tawil, Satish Tickoo, Maria Tretiakova, Isabel Trias, Lawrence True, Toyonori Tsuzuki, Monika Ulamec, Theodorus Van der Kwast, Geert JLH van Leenders, Bas van Rhijn, Funda Vakar Lopez, Murali Varma, Elsa Velazquez, Mariavittoria Vescovo, Gang Wang, Anne Warren, Joshua Warrick, Sean Williamson, Sara Wobker, Chin-Lee Wu, Huihui Ye, Xiaolin Zi, Hong Zhang
Cheng L, Kristiansen G. International Society of Urological Pathology (ISUP) Multidisciplinary Consensus Conference on Premalignant and Precursor Lesions of the Genitourinary Organs: Current Evidence and Future Directions. Am J Surg Pathol. 2026 Mar 27. doi: 10.1097/PAS.0000000000002542. Epub ahead of print. PMID: 41891794.
International Society of Urological Pathology Consensus Meeting 2024: Working Group 2 Preneoplastic and Precursor Lesions of the Urinary Bladder
Bremmer F, Colecchia M, Collins K, Acosta AM, Gupta S, Gordetsky JB, Maclean F, Meyts ER, Dieckmann KP, Kaushal S, Srigley JR, Adra N, Gilligan T, Daugaard G, Looijenga LHJ, Kristiansen G, Cheng L, Tickoo SK; Members of the ISUP GU Cancer Precursor Consensus Panel. International Society of Urological Pathology (ISUP) Consensus Conference on Precursor Lesions: Working Group 4 Precursor Lesions of Testis Results of a Premeeting Survey. Am J Surg Pathol. 2026 Feb 23. doi: 10.1097/PAS.0000000000002523. Epub ahead of print. PMID: 41724745.